abstract：OBJECTIVE:This study was aimed to explore parents' experience of assisting children affected by tuberous sclerosis complex (TSC) with subependymal giant-cell astrocytoma (SEGA) manifestation, in order to understand their caring needs and expectation of support. SETTING AND PROCEDURE:The study was designed according to...

journal_title：BMJ open

authors： Graffigna G,Bosio C,Cecchini I

更新日期：2013-12-06 00:00:00

abstract：OBJECTIVE:To assess the impact of chronic kidney disease (CKD) and cardiovascular comorbidity on mortality in a multiethnic primary care population. DESIGN:Retrospective cohort study. SETTING:Inner-city primary care trust in West Midlands, UK. PARTICIPANTS:Individuals aged 40 years and older, of South Asian, black o...

journal_title：BMJ open

authors： Jesky M,Lambert A,Burden AC,Cockwell P

更新日期：2013-12-03 00:00:00

abstract：OBJECTIVE:To explore the pathway to diagnosis of type 1 diabetes (T1D) in children from the perspective of the child, family and general practitioner (GP). DESIGN:Qualitative interview study. PARTICIPANTS:Parents of children aged 1 month to 16 years diagnosed with new onset T1D within the previous 3 months, children ...

journal_title：BMJ open

authors： Usher-Smith JA,Thompson MJ,Walter FM

更新日期：2013-12-03 00:00:00

abstract：OBJECTIVES:Serum ferritin and body mass index (BMI) have been reportedly associated with coronary artery disease (CAD) risk. The aim of the present study was to explore the interaction between serum ferritin and BMI on CAD risk. DESIGN:Hospital-based case-control study. SETTING:Patients with CAD and the controls were...

journal_title：BMJ open

authors： Zhou Y,Liu T,Jia C

更新日期：2013-11-27 00:00:00

abstract：OBJECTIVES:To analyse the trends and trend changes in myocardial infraction (MI) and coronary heart disease (CHD) admissions, to investigate the effects of the 2007 smoke-free legislation on these trends, and to consider the policy implications of any findings. DESIGN SETTING:Liverpool (city), UK. PARTICIPANTS:Hospit...

journal_title：BMJ open

authors： Liu A,Guzman Castillo M,Capewell S,Lucy J,O'Flaherty M

更新日期：2013-11-25 00:00:00

abstract：OBJECTIVE:To determine whether the association between obesity and coronary heart disease (CHD) in Aboriginal adults depends on age. DESIGN, SETTING AND PARTICIPANTS:A cohort study with up to 20 years of follow-up of 849 participants aged 18-76 years in a remote Aboriginal community in the Northern Territory of Austra...

journal_title：BMJ open

authors： Wang Z,Hoy WE

更新日期：2013-11-25 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of diabetes mellitus (DM) and new detection of DM using fasting plasma glucose (FPG) and 2 h plasma glucose (2-hPG) in hypertensive outpatients in China. DESIGN:Multicenter cross-sectional study. SETTING:46 hospitals in China. PARTICIPANTS:Study patients were consecutively re...

journal_title：BMJ open

authors： Liu J,Zhao D,Liu J,Qi Y,Sun J,Wang W

更新日期：2013-11-20 00:00:00

abstract：INTRODUCTION:Rehabilitation is a key element in most cancer care policies in recognition of the often unmet physical, psychological and social needs among the rising numbers of patients with cancer. A systematic assessment of patients' needs and available rehabilitation services constitute the foundation for timely, co...

journal_title：BMJ open

authors： Kristiansen M,Adamsen L,Hendriksen C

更新日期：2013-11-19 00:00:00

abstract：OBJECTIVES:The aim of this study was to (1) demonstrate the development and testing of tools and procedures designed to monitor and assess the integrity of a complex intervention for chronic pain (COping with persistent Pain, Effectiveness Research into Self-management (COPERS) course); and (2) make recommendations bas...

journal_title：BMJ open

authors： Mars T,Ellard D,Carnes D,Homer K,Underwood M,Taylor SJ

更新日期：2013-11-15 00:00:00

abstract：OBJECTIVES:We investigated the clinical characteristics of patients with stroke recurrence in the first year after cardioembolic stroke, and determined the predictors associated with recurrence. DESIGN:A prospective cohort study. SETTING:Multicentre study at the Fukuoka prefecture in Japan. PARTICIPANTS:We enroled 2...

journal_title：BMJ open

authors： Kuwashiro T,Sugimori H,Ago T,Kuroda J,Kamouchi M,Kitazono T,FSR Investigators (see appendix).

更新日期：2013-11-14 00:00:00

abstract：OBJECTIVES:Intention to treat (ITT) is an analytic strategy for reducing potential bias in treatment effects arising from missing data in randomised controlled trials (RCTs). Currently, no universally accepted definition of ITT exists, although many researchers consider it to require either no attrition or a strategy t...

journal_title：BMJ open

authors： Del Re AC,Maisel NC,Blodgett JC,Finney JW

更新日期：2013-11-12 00:00:00

abstract：OBJECTIVE:CT-diagnosed emphysema is associated with poor prognosis in chronic obstructive pulmonary disease (COPD). Its clinical impacts on prognoses of asthma with chronic airflow obstruction (CAO) are not well known. We sought to compare mortalities and prognostic factors in COPD and asthma with CAO by the presence o...

journal_title：BMJ open

authors： Kurashima K,Fukuda C,Nakamoto K,Takaku Y,Hijikata N,Hoshi T,Kanauchi T,Ueda M,Takayanagi N,Sugita Y,Araki R

更新日期：2013-11-04 00:00:00

abstract：OBJECTIVES:To investigate whether gestational age modifies the association of airway infections that result in hospital admission during the first year after birth, with subsequent asthma risk after age 5 years. SETTING:Hospital inpatients and a general population comparison group in Sweden followed for subsequent dia...

journal_title：BMJ open

authors： Montgomery S,Bahmanyar S,Brus O,Hussein O,Kosma P,Palme-Kilander C

更新日期：2013-10-29 00:00:00

abstract：INTRODUCTION:After a diagnosis of localised breast cancer, overweight, obesity and weight gain are negatively associated with prognosis. In contrast, maintaining an optimal weight through a balanced diet combined with regular physical activity appears to be effective protective behaviour against comorbidity or mortalit...

journal_title：BMJ open

authors： Touillaud M,Foucaut AM,Berthouze SE,Reynes E,Kempf-Lépine AS,Carretier J,Pérol D,Guillemaut S,Chabaud S,Bourne-Branchu V,Perrier L,Trédan O,Fervers B,Bachmann P

更新日期：2013-10-28 00:00:00

abstract：OBJECTIVES:To understand the publishing priorities, especially in relation to open access, of 10 UK biomedical research funders. DESIGN:Semistructured interviews. SETTING:10 UK biomedical research funders. PARTICIPANTS:12 employees with responsibility for research management at 10 UK biomedical research funders; a p...

journal_title：BMJ open

authors： Collins E

更新日期：2013-10-23 00:00:00

abstract：OBJECTIVE:Providing services to rural dwelling minority cultural groups with serious chronic disease is challenging due to access to care and cultural differences. This study aimed to describe service providers' perspectives on health services delivery for Aboriginal people receiving haemodialysis for end-stage kidney ...

journal_title：BMJ open

authors： Rix EF,Barclay L,Wilson S,Stirling J,Tong A

更新日期：2013-10-23 00:00:00

abstract：OBJECTIVE:To investigate if continuation rates in first-time users of oral hormonal contraceptives differed between different formulations and to measure if the rates were related to the prescribing categories, that is, physicians and midwives. DESIGN:A longitudinal national population-based registry study. SETTING:T...

journal_title：BMJ open

authors： Josefsson A,Wiréhn AB,Lindberg M,Foldemo A,Brynhildsen J

更新日期：2013-10-18 00:00:00

abstract：INTRODUCTION:Parkinson's disease (PD) is the second most common neurodegenerative disorder in developed countries. There is an increasing interest in the use of mindfulness-related interventions in the management of patients with a chronic disease. In addition, interventions that promote personal control, stress-manage...

journal_title：BMJ open

authors： Advocat J,Russell G,Enticott J,Hassed C,Hester J,Vandenberg B

更新日期：2013-10-10 00:00:00

abstract：OBJECTIVE:To examine consumers' confidence in their own, and also in other people's, over-the-counter (OTC) skills and to describe their attitude towards the availability of OTC painkillers. Moreover we examined the association between confidence in OTC skills and attitudes. DESIGN:Cross-sectional survey. Mixed method...

journal_title：BMJ open

authors： Brabers AE,Van Dijk L,Bouvy ML,De Jong JD

更新日期：2013-09-25 00:00:00

abstract：INTRODUCTION:Patellofemoral pain (PFP) can cause significant pain leading to limitations in societal participation and physical activity. An international expert group has highlighted the need for a classification system to allow targeted intervention for patients with PFP; we have developed a work programme systematic...

journal_title：BMJ open

authors： Selfe J,Callaghan M,Witvrouw E,Richards J,Dey MP,Sutton C,Dixon J,Martin D,Stokes M,Janssen J,Ritchie E,Turner D

更新日期：2013-09-23 00:00:00

abstract：OBJECTIVES:Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) emergence is a major public health concern. This study was aimed at assessing risk factors for persistently carrying MRSA in veal calf farmers and their family members. We also evaluate the dynamics of MRSA environmental load during t...

journal_title：BMJ open

authors： Dorado-García A,Bos ME,Graveland H,Van Cleef BA,Verstappen KM,Kluytmans JA,Wagenaar JA,Heederik DJ

更新日期：2013-09-19 00:00:00

abstract：BACKGROUND:Although many studies have assessed poststroke objective cognitive impairment, only a few have evaluated patients' subjective cognitive complaints (SCC). Although these SCC are found to be common in the early and chronic phases after stroke, knowledge about their risk factors, course over time, differences w...

journal_title：BMJ open

authors： van Rijsbergen MW,Mark RE,de Kort PL,Sitskoorn MM

更新日期：2013-09-19 00:00:00

abstract：OBJECTIVES:To describe the clinical profile of Brazilian patients with type 2 diabetes attending the public healthcare system and identify factors associated with poor glycaemic control. DESIGN:Cross-sectional study. SETTING:14 centres in five regions of Brazil, including primary care units and outpatient clinics of ...

journal_title：BMJ open

authors： Viana LV,Leitão CB,Kramer CK,Zucatti AT,Jezini DL,Felício J,Valverde AB,Chacra AR,Azevedo MJ,Gross JL

更新日期：2013-09-18 00:00:00

abstract：INTRODUCTION:Obese patients with type 2 diabetes undergoing bariatric surgery experience significant and lasting weight loss and improved glycaemic control. However, bariatric surgical procedures such as Roux-en-Y gastric bypass are irreversible and associated with considerable short-term and long-term risks. The EndoB...

journal_title：BMJ open

authors： Rohde U,Hedbäck N,Gluud LL,Vilsbøll T,Knop FK

更新日期：2013-09-13 00:00:00

abstract：OBJECTIVES:To compare the efficacy of hypnotherapy versus gabapentin for the treatment of hot flashes in breast cancer survivors, and to evaluate the feasibility of conducting a clinical trial comparing a drug with a complementary or alternative method (CAM). DESIGN:Prospective randomised trial. SETTING:Breast health...

journal_title：BMJ open

authors： Maclaughlan David S,Salzillo S,Bowe P,Scuncio S,Malit B,Raker C,Gass JS,Granai CO,Dizon DS

更新日期：2013-09-10 00:00:00

abstract：OBJECTIVES:To investigate the prognostic value of the neurocognitive status measured by screening instruments, the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE), individually and in combination with the stroke severity scale, the National Institute of Health Stroke Scale (NIHSS), obtaine...

journal_title：BMJ open

authors： Dong Y,Slavin MJ,Chan BP,Venketasubramanian N,Sharma VK,Crawford JD,Collinson SL,Sachdev P,Chen CL

更新日期：2013-09-03 00:00:00

abstract：OBJECTIVES:Accreditation in France relies on a mandatory 4-year cycle of self-assessment and a peer review of 82 standards, among which 14 focus priority standards (FPS). Hospitals are also required to measure yearly quality indicators (QIs-5 in 2010). On advice given by the accreditation committee of HAS (Haute Autori...

journal_title：BMJ open

authors： Guérin S,Le Pogam MA,Robillard B,Le Vaillant M,Lucet B,Gardel C,Grenier C,Loirat P

更新日期：2013-08-30 00:00:00

abstract：INTRODUCTION:Idiopathic Environmental Intolerance (IEI) attributed to electromagnetic fields (EMF) refers to self-reported sensitivity mainly characterised by the attribution of non-specific physical symptoms to low-level EMF exposure emitted from sources such as mobile phones. Scientific studies have not provided evid...

journal_title：BMJ open

authors： Bogers RP,Bolte JF,Houtveen JH,Lebret E,van Strien RT,Schipper CM,Alkadhimi M,Baliatsas C,van Kamp I

更新日期：2013-08-29 00:00:00

abstract：OBJECTIVES:To examine the prevalence of binge drinking in adolescence and its persistence into adulthood in an Australian cohort. DESIGN:15-year prospective cohort study. SETTING:Victoria, Australia. PARTICIPANTS:1943 adolescents were recruited from secondary schools at age 14-15 years. PRIMARY OUTCOME MEASURES:Lev...

journal_title：BMJ open

authors： Degenhardt L,O'Loughlin C,Swift W,Romaniuk H,Carlin J,Coffey C,Hall W,Patton G

更新日期：2013-08-19 00:00:00

abstract：OBJECTIVE:To develop and externally validate a risk algorithm (QAdmissions) to estimate the risk of emergency hospital admission for patients aged 18-100 years in primary care. DESIGN:Prospective open cohort study using routinely collected data from general practice linked to hospital episode data during the 2-year st...

journal_title：BMJ open

authors： Hippisley-Cox J,Coupland C

更新日期：2013-08-19 00:00:00

abstract：OBJECTIVES:To develop and measure the effectiveness and acceptability of a pharmacy-based chlamydia screening intervention called Emergency Contraception Mediated Pharmacy Access to Chlamydia Testing (ECOMPACT). DESIGN:Selective, opportunistic and cross-sectional study targeting asymptomatic women requesting emergency...

journal_title：BMJ open

authors： Gudka S,Marshall L,Creagh A,Clifford RM

更新日期：2013-08-17 00:00:00

abstract：OBJECTIVES:National guidelines recommend mobilisation in bed as early as possible after acute stroke. Little is known about the influence of upright positioning on real-time cerebral flow variables in patients with stroke. We aimed to assess whether cerebral blood flow velocity (CBFV) changes significantly after uprigh...

journal_title：BMJ open

authors： Aries MJ,Elting JW,Stewart R,De Keyser J,Kremer B,Vroomen P

更新日期：2013-08-14 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening illness of unknown aetiology, with no proven pharmacological treatments. There is a limited evidence base indicating that the disease negatively affects quality of life, leading to increased dependence, restrictions on daily activities ...

journal_title：BMJ open

authors： Byrne A,Sampson C,Baillie J,Harrison K,Hope-Gill B,Hubbard R,Griffiths G,Nelson A

更新日期：2013-08-07 00:00:00

abstract：OBJECTIVE:To determine the feasibility of therapy-based, risk-stratified follow-up guidelines for childhood and teenage cancer survivors by evaluating adverse health outcomes in a survivor cohort retrospectively assigned a risk category. DESIGN:Retrospective cohort study. SETTING:Tertiary level, single centre, paedia...

journal_title：BMJ open

authors： Edgar AB,Duffin K,Borthwick S,Marciniak-Stepak P,Wallace WH

更新日期：2013-08-02 00:00:00

abstract：OBJECTIVES:Few studies have focused on pulmonary arterial hypertension (PAH) associated with connective tissue diseases (CTDs). The optimal treatment for CTD-PAH has yet to be established. DESIGN:Meta-analysis of the data from evaluations of treatment for PAH generally (19 studies) and CTD-PAH specifically (nine studi...

journal_title：BMJ open

authors： Kuwana M,Watanabe H,Matsuoka N,Sugiyama N

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Persistent postconcussive symptoms (PCSs) is the persistence of somatic, cognitive, physical, psychological and/or behavioural changes lasting more than 1 month following concussion. Persistent concussion impacts the quality of life through impaired cognition, memory and attention affecting school performa...

journal_title：BMJ open

authors： Zemek R,Osmond MH,Barrowman N,Pediatric Emergency Research Canada (PERC) Concussion Team.

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To examine the use of selective serotonin reuptake inhibitors (SSRIs) among Danish women of childbearing age according to lifestyle factors. DESIGN:Cross-sectional survey. SETTING:The Central Denmark Region. PARTICIPANTS:4234 women (71.5% of the invited women) aged 25-44 years who participated in a public ...

journal_title：BMJ open

authors： Laugesen K,Telén Andersen AB,Nørgaard M,Nielsen RB,Thomsen RW,Larsen FB,Sørensen HT

更新日期：2013-07-31 00:00:00

abstract：INTRODUCTION:Whether acupuncture is efficacious for patients with functional dyspepsia is still controversial. So we designed a randomised controlled trial to settle the problem. METHODS AND ANALYSIS:We designed a multicentre, two-arm, sham-controlled clinical trial. 200 participants with functional dyspepsia will be ...

journal_title：BMJ open

authors： Zheng H,Xu J,Li J,Li X,Zhao L,Chang X,Liu M,Gong B,Li X,Liang F

更新日期：2013-07-30 00:00:00

abstract：OBJECTIVES:In order to assess if ambient air pollution in urban areas could be related to alterations in male/female ratio this study objectives to evaluate changes in ambient particulate matter (PM10) concentrations after implementation of pollution control programmes in São Paulo city and the secondary sex ratio (SRR...

journal_title：BMJ open

authors： Miraglia SG,Veras MM,Amato-Lourenço LF,Rodrigues-Silva F,Saldiva PH

更新日期：2013-07-26 00:00:00

abstract：OBJECTIVES:There is growing evidence that antihypertensive agents, particularly centrally acting ACE inhibitors (CACE-Is), which cross the blood-brain barrier, are associated with a reduced rate of cognitive decline. Given this, we compared the rates of cognitive decline in clinic patients with dementia receiving CACE-...

journal_title：BMJ open

authors： Gao Y,O'Caoimh R,Healy L,Kerins DM,Eustace J,Guyatt G,Sammon D,Molloy DW

更新日期：2013-07-25 00:00:00